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Phase I/II trial of the MEK1/2 inhibitor trametinib (GSK1120212) in relapsed/refractory myeloid malignancies: Evidence of activity in patients with RAS mutation-positive disease

Figure 3 Genetics of the FXS Model Mouse The fundamental difference between commonly used FXS model mice ( Fmr1 /y mice 8 ) and patients is that mice never have any FMRP, beginning with their very first moment of existence, whereas in patients, the gene is active at least until the 10 th week of gestation (Devys et al., 1992

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elegans IFDs and hNFL clearly localize similarly to aggresome-like compartments (Fig