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Effects of nutritionally induced obesity on metabolic pathways of zebrafish

Oh J, Byrd AL, Deming C, et al

Schmidlin CJ, Dodson MB, Madhavan L, Zhang DD

Single site mutations at asparagine residues were shown to result in a functionally active yet slightly less thermally stable version of the enzyme in vitro, while knockout of all asparagine residues resulted in an accumulation of the uncleaved, propeptide form of the enzyme