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Their 7th single, Love Machine, was released in 1999 and was their first to sell over a million copies, an achievement that was repeated with Koi no Dance Site, Happy Summer Wedding, Renai Revolution 21 and more, breaking multiple Oricon chart records held by female groups

Jain, A., et al.,p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

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Nevertheless, the dysregulation of copper homeostasis, whether towards excess or deficiency, can lead to pathological alterations, such as atherosclerosis