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Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) promotes MDSCs formation and expansion, prohibiting CD8 + T cells from normal function through exosomes, creating an immunosuppressive TME [324]

Mol Neurobiol 60(4):19291948 Maegawa H, Niwa H (2021) Generation of mitochondrial toxin rodent models of Parkinsons disease using 6-OHDA, MPTP, and rotenone

From a metabolic standpoint, directly inhibiting LDHA or employing glycolysis inhibitors can curtail lactate production at its source, thereby mitigating CIRI and aiding in the restoration of cellular function [113, 117]