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By January 1963 Nordin had made enough progress to present to what Jerne described as 'a plate with hundreds of tiny plaques that, after staining the red cell background with benzidine, looked like stars in a cloudless sky.' Sent the following month to Science Jerne says 'The importance of being able to count the number of cells secreting a specific antibody was immediately clear to everybody to whom we showed these pictures' (Jerne, 1981)

In addition, Tregs in SLE patients are usually of weaker regulatory function towards inflammation, and medications with the capacity to enhance Treg function can restore immune homeostasis in these individuals (130133)