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Once modified, these cells are expanded ex vivo for a short period of time (~7 days) and then delivered to the patient, generally intravenously ( In 1989, the first synthetic receptor was designed by combining the constant region of the T-cell receptor and the variable region of an antibody ( 2.1 Generation of CAR-T cells In general, CAR-T cell manufacturing involves customizing the patient T cells to avoid allogeneic rejection or graft-versus-host disease ( in vitro

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