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For example, IL-10 receptor mutations result in a severe, early onset colitis, which has been successfully treated by bone marrow transplant [115, 116]

On the other hand, in the chronic hyperglycemia condition in diabetes, O-GlcNAc transferase reduces the transcription of SERCA2, which results in decreased calcium reuptake and impaired relaxation (55)

6df, GPX4 protein levels were also decreased after treatment with heme, FAC, and erastin in the HNPCs, indicating that all three of these treatments can induce intracellular ROS production and cell death

Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction