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Women who report severe hot flashes have been shown to: These findings suggest that VMS are not merely driven by temperature dysregulation alone, but are linked to changes in vascular tone, nitric oxide signaling, and oxidative stress

In line, with this finding RVX exerted anti-inflammatory activity against cisplatin-induced testicular damage 35 and chronic unpredicted mild stress-induced depression 56

Whether pain management is best accomplished by the primary treating clinician and/or by a multidisciplinary team or other pain specialists should be determined by the individual clinician in consultation with the patient

Sood, L., Sterns, R