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Semaglutide is a glucagon-like peptide-1 (GLP-1) analog that was initially approved in 2020 as a treatment method for improving glycemic control in patients with Type 2 diabetes

[DOI] [PubMed] [Google Scholar] 111.Tseilikman V.E., Tseilikman O.B., Pashkov A.A., Ivleva I.S., Karpenko M.N., Shatilov V.A., Zhukov M.S., Fedotova J.O., Kondashevskaya M.V., Downey H.F., et al

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Tomonori Kanda and colleagues published a study reporting that even in patients with normal renal function, there was an increase in T1 signal intensity in deep brain nuclei that correlated with the cumulative number of GBCA administrations with confirmed gadolinium deposition in both brain and extracranial tissues ( FIGURE 1 Currently, multiple studies have documented gadolinium deposits in bone, brain, and renal tissue, even in individuals with normal renal function and tried to explain the pathologic mechanisms involved (Cunningham et al.)