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Since the skin is essentially organized in two dimensions, with the third dimension almost negligible compared to the other two, devices for vascular skin tissue engineering have the possibility of obtaining notable successes in localized revascularization processes, as previously discussed [24]

At the cellular and molecular levels, the expression of femoral OPG and RANKL proteins, fecal SCFAs and colonic FOXP3 cells, and ZO-1 and Occludin proteins were elevated, together with the upregulation of serum cytokines IL-10 and TGF- and the downregulation of IL-17 and TNF-