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Since the goal of the current study was to profile ADT-related metabolomic changes, the untargeted approach was preferable and allowed for a more global metabolomic profiling

Although L-carnitine is endogenously biosynthesized in certain tissues such as the liver, kidneys and brain (Koeth et al

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Following oral ingestion, rapid elevation in plasma concentrations of both d 9 -BB and d 9 -l-carnitine was observed, followed by d 9 -TMAO generation after a lag phase (Figure 2, AC, filled circles)