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Over time, a substantial proportion of patients develop a progressive phase, typically 10 to 15 years after disease onset, characterized by gradual accumulation of disability and ongoing neurodegeneration that becomes less directly associated with the acute inflammatory activity [104]

Example: Heavy drinking depletes NAD and glutathione, impairing energy metabolism and antioxidant defense

Generally, such organizations know the populations they serve and their communities and may have the infrastructure or systems in place to help coordinate supportive services that address social determinants of health (SDOH) or serve as a source from which ACOs can receive information regarding community needs

Colonic bacterial metabolites and human health