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Meanwhile, plasma cholesterol levels were reduced by 30%, and the blood lipid profile recovered to nearly normal levels comparable to lean mice.Another 28day experiment demonstrated that 5Amino1MQ Peptide treatment dosedependently suppressed body weight gain and fat accumulation in obese mice, improved insulin sensitivity and hepatic lipid metabolism, without obvious side effects-no abnormalities were observed in food intake, physical activity, or liver and kidney function parameters

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Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance