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found that inhibiting the GPX4 with RAS-selective lethal small molecule 3 (RSL3) enhances the antitumor effect of cisplatin (Zhang et al., 2020)

The capacity of iron chelation to influence other regulated cell death modalities is less well studied, but this possibility should be carefully considered when evaluating why iron chelators have, in some cases, exacerbated neurodegenerative conditions featuring multiple overlapping cell death mechanisms

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