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This mechanism is considered a physiological basis of the behavioral sickness response that humans and animals display during infections (Poon et al., 2015)

It has been documented in a meta-analysis study and a systematic review that elevated levels of 8-OHdG in biological samples, such as urine, serum, or tissue, are indicative of increased oxidative stress (182, 183)

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Statistical analysis Data throughout the experiment are presented as mean standard deviation (SD) or mean standard error (SEM), analyzed using GraphPad Prism