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The data presents a head-to-head comparison with industry-leading competitors.

Future studies will reveal the applicability of our model, for example, to activate enzymatically inactive glutaredoxins, to alter the sensitivity and responsiveness of glutaredoxin-coupled fluorescent redox sensors, to further address the catalytic mechanism with GSSCys, HEDS and physiological substrates, or to design specific transition-state inhibitors

doi: 10.1038/s41392-019-0079-0 154 KellyBONeillLAJ

High-resolution respirometry for inguinal white adipose After adding the tissue into the respiration chamber, the chamber was closed and allowed to equilibrate before adding any substrates