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Such Sirts have the potential to downregulate the NF-B pathway, which helps reduce neuroinflammation (Paxinou et al., 2001) Sirt2 has been reported to deacetylate NOD-like receptor pyrin domain containing 3 (NLRP3) and prevent aging-related chronic inflammation (Li et al., 2021), while Sirt3 inhibits NLRP3 by reducing mitochondrial damage and mtDNA release (He et al., 2020)

Divito SJ, Kupper TS (2014) Inhibiting Janus kinases to treat alopecia areata

Gemcitabine is a pyrimidine analog that can be doped into replicating DNA to indirectly inhibit the DNA synthesis process

The expression of three genes associated with good oocyte quality (PGK1, RGS2, and CDC42) was significantly higher in the MYO-treated group, although no significant difference in the reactive oxygen species concentration in follicular fluid was noted, suggesting that MYOs effect on oocyte quality is independent of its antioxidant action [44]