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Dodick DW, Migraine (2018) Lancet 391:13151330

One factor in feeling sleepy every night is the buildup of adenosine in the brain

10.1080/15438600490424389 Exp

While a definitive causal relationship has thus far been challenging to define experimentally, substantial work has focused on elucidating the aberrant cellular signaling and phenotypic changes in cardiac cells that take place in the context of ECD (Figure 2)