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The long-term safety profile is well-characterized, and the cardiovascular benefit is proven through the SELECT trial

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Endocrinology 140:53915401 Glowinski J, Kemel ML, Desban M, Gauchy C, Lavielle S, Chassaing G, Beaujouan JC, Tremblay L (1993) Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptors

This is one of the simplest fixes available, as allowing the vial or pen to reach room temperature for 30 minutes before injection dramatically reduces the burning sensation