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Further studies revealed that ATF1 and ATF2 exert synergistic effects on pathogen recognition

Depending on their role in autophagosome biogenesis, ATG proteins can be classified into the following functional clusters: (1) the ULK1 kinase core, (2) the class III PI3K complex I, (3) the ATG2-ATG18/WIPI complex, (4) the ATG9A trafficking system, (5) the ATG5/ATG12-conjugation system, and (6) the ATG8/LC3 conjugation system

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The results revealed that all GPX4 isoforms are expressed in this cell line and, more interestingly, that their absolute abundance followed the same sequence observed in HT22 cells, though in this case the amount of the most prominent isoform, namely c- GPX4 , was notably higher (about four orders of magnitude) than any other isoform