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Id1 is a critical mediator in TGF--induced transdifferentiation of rat hepatic stellate cells

With the lung infiltration of neutrophils and macrophages triggered by CS, proinflammatory cytokines such as interleukin -1(IL-1) and tumor necrosis factor- (TNF-) induce a cascade of amplification effects of inflammation, and activate nuclear factor- B (NF- B) (Di Stefano et al., 2002)

Knocking out the Bmal1 gene in mice results in the immediate and complete loss of circadian rhythms in continuous darkness, providing direct evidence for its indispensable role in the generation of circadian rhythms