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This selective binding initiates both genomic and non-genomic estrogenic responses that disrupt normal hormonal balance ( 3.1.2 Membrane receptor and calcium signaling dysregulation 3.1.2.1 Calcium homeostasis disruption EED exposure significantly disrupts intracellular calcium homeostasis, leading to aberrant Ca 2+ signaling patterns that compromise sperm function

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Conclusion The application of pathway analysis using PathVisio on multiple datasets led to the identification of several signaling pathways and cellular processes that play an important role in prostate cancer development and that subsequently were assigned to three main biological processes, including cholesterol biosynthesis, epithelial-to-mesenchymal transition and an increased metabolic activity