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For example, the phrase treating a patient with a disease or disorder caused or characterized by excess weight may reduce the severity of the disease or disorder to such a degree that the subject no longer experiences discomfort and/or altered function

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HIF targets include genes encoding mediators of angiogenesis such as vascular endothelial growth factor (VEGF) and VEGF receptors, enzymes of the glycolytic pathway such as hexokinase 2, lactate dehydrogenase, and glucose transporters (GLUT-1, GLUT-3), as well as CA IX

Over the following 30 years, more than 130 peer-reviewed papers have followed, the vast majority from his group and primarily in animal models