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Clinical research The foundational characterization of GHK-Cu as a growth-modulating plasma tripeptide that functions by facilitating copper uptake into cells was published in Nature by Pickart et al

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GHK-Cu plays a role in wound healing by stimulating tissue regeneration, angiogenesis, and controlled inflammatory responses

This feature and its negative charge at physiological pH imply the existence of specific carriers to import GSH from the cytosol to the mitochondrial matrix, where it plays a key role in defense against respiration-induced reactive oxygen species and in the detoxification of lipid hydroperoxides and electrophiles