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Among the PRMT family, PRMT1 stands out due to its broad substrate specificity and abundance in various cell types, including renal cells [11, 13]

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The researchers administered glutathione-MDI conjugates to mice and found that MDI is transferred to a particular lysine residue in albumin, probably via a transcarbamoylation reaction

The studies tested various doses including 0.25 mg, 0.5 mg, and 1 mg daily via subcutaneous administration over periods ranging from single doses to 24 weeks of continuous therapy