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Overall, our binding analysis and Th-T assays of Syn 1103 with various interactors tested suggest that random cellular proteins are sequestered within inclusions due to the promiscuous binding nature of Syn 1103 , rather than exerting any inhibitory effect on its aggregation

Furthermore, those parameters are associated with the success of antidepressant treatment

These matrix-dependent differences are particularly relevant for dietary supplements, as formulation choice can markedly influence exposure profiles

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