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We are continuing to accept orders during this time

Our observation that intracellular NA concentrations did not increase following NNMT inhibition extends previous studies that showed NA concentrations were largely unaffected following NNMT knockdown with either adenovirus[39] or anti-sense oligonucleotides (ASOs).[12] It is possible that significant accumulation of NA in adipocytes (and other tissues) is prevented by rapid conversion of NA to NMN and subsequent NAD + synthesis or transport to the extracellular environment.[27] Importantly, NNMT inhibition potentiated the absolute intracellular concentrations of NAD + and SAM, without altering the levels of NA and SAH in the adipocytes

Clinical observation, waist circumference, and patient-reported changes across sleep, energy, and recovery give a more complete picture of how the protocol is actually working

Pernicious anaemia or malabsorption disorders typically require intramuscular hydroxocobalamin 1,000 g three times weekly initially, then maintenance doses every 23 months