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Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan

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This raises the pertinent question whether models, which rely on the deletion of an entire cell population, such as MCs, which are notoriously heterogeneous, highly plastic and adaptable in nature, and excel in their capacity to rapidly shift the spectrum of mediators released and surface markers expressed in distinct signaling environments (e.g., homeostatic versus inflammatory settings), are not overly simplistic