dihexa dendritic spine formation Comment "curious" for the full newsletter. 👇 There's a molecule rumored to be “10 million times” more powerful than BDNF for synaptogenesis, neuron growth, learning, and memory. It's called Dihexa. It's gaining Dentritic spines : structure, dynamics

[PubMed: 37647008] [PubMed: 25631887] Lyophilized vs solution: stability basics Lyophilized material: generally more stable when protected from moisture and temperature excursions

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To date, incretin-based approaches for obesity management appear as the most promising and rapidly developing (Supplementary Table 1), with innovations such as once-weekly (OW) injectable triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), cagrilintide (long-acting amylin analogue)/semaglutide 2.4 mg (CagriSema) combination, GCGR/GLP-1R dual agonists, high-dose oral semaglutide, and oral non-peptide GLP-1 receptor agonist orforglipron, with relevant implications in terms of patients compliance and environmental sustainability

Because peptides are naturally occurring and highly specific in their action, they carry minimal risk and are generally well-tolerated, with little to no side effects