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The following have been shown to shift estrogen metabolism toward the 2-hydroxyestrone pathway[2]: Exercise and weight loss Isoflavones such as soy and flaxseed Omega-3 fatty acids Green tea polyphenol Cruciferous vegetables and broccoli derivatives, including indole-3-carbinol (I3C) and diindolylmethane (DIM, result of I3C after activation by stomach acid) A healthy lifestyle that allows for a normal weight helps to decrease the risk of insulin resistance from metabolic syndrome