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4.1.1 Basic function of the HPA axis When an individual confronts a stressor, the hypothalamic-pituitary-adrenal (HPA) axis initiates a stress response by a range of endocrine feedback mechanisms (Kageyama et al., 2021)

This study identifies a comprehensive epigenetic mechanism by which dietary genistein exerts its chemopreventive effects on the colon during early stage carcinogenesis

FDA, July 2324, 2026 Pharmacy Compounding Advisory Committee meeting and introductory briefing document

The complementary mechanisms allow for enhanced efficacy while potentially allowing lower doses of individual components, which may reduce side effect risks