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Depending on the metabolic fate in the cell, two types of linkers are used in most ADC drugs, including cleavable linkers ( that utilize the inherent properties of the tumor cells for selective release of cytotoxins from ADCs) and non-cleavable linkers (that rely on complete degradation of the antibody after internalization of the ADC)

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Exercise As you learned in Example 8, a 0.225 M solution of ethylamine (CH 3 CH 2 NH 2 , p K b = 3.19) has a pH of 12.08 and a percent ionization of 5.4% at 20C