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These metabolites can exert either neuroprotective effects or neurotoxic effects

[Abstract]2024 Jul 1:829:111873

Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells

Then, two key effectors regulating mRNA translation, p70S6 kinase 1 (S6K1) and eIF4E binding protein (4EBP), will be phosphorylated, thereby promoting protein synthesis (131)