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The fact that these are spread across a structure-based phylogenetic tree of enteroviruses supports the hypothesis that there is a unified assembly mechanism common to the majority of enteroviruses (Fig

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doi: 10.1159/000477119 7 ChambersS

Based on the primary efficacy endpoint (mortality), the non-inferiority of sildenafil 80 mg TID arm versus 5 mg TID arm was met using a 2-sided significance level of 0.003 for the interim analysis