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Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf 2-Gpx 4 signaling pathway

As two negative regulators of p53, MDM2 and MDMX facilitate ferroptosis with or without p53, most likely by altering the lipid profile of cells (Venkatesh et al., 2020), which is confirmed by evidence that with the treatment of MDM2 inhibitor nutlin-3, p53 expression increases and leads to the suppression of X c system inhibitor-induced ferroptosis in HT-1080 cells (Tarangelo et al., 2018)

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To further demonstrate activation of the TSS pathway by DMF, we investigated the metabolism of serine for de novo cysteine biosynthesis by 13 C 3 -serine tracing (Fig