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doi: 10.1097/00005768-200010000-00010 51 BjornebekkAWestlyeLTWalhovdKBJorstadMLDue-TonnessenPHullsteinIRet al

The p53 reactivator PRIMA-1MET synergises with 5-fluorouracil to induce apoptosis in pancreatic cancer cells

Its an IV infusion containing glutathione, a powerful antioxidant

The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]