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Remarkably, KDS12025 demonstrated significant efficacy in mitigating RA pathology, as evidenced by a reduction in the CIA score, a clinical measure of joint inflammation severity, and improvements in histological parameters, including synovial hyperplasia and cartilage destruction, as shown via H&E and toluidine blue staining (Supplementary Fig

Moreover, in a study on smokers, supplementation with Haematococcus -derived ASTA for three weeks at daily doses between 5 and 40 mg resulted in a dose-dependent reduction in F2-isoprostane levels, a lipid marker of oxidative stress [37]

Despite significant advances in mechanical treatments such as rotational atherectomy, these methods are passive treatments for advanced calcification (191)

As a skilled diagnostician, Dr