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Generally, gene therapy vectors will be as the expression vectors described above in the sense that they comprise the nucleotide sequence encoding agent to be expressed, whereby the nucleotide sequence is operably linked to the appropriate regulatory sequences as indicated above

doi:10.1007/s00425-008-0772-7 Lehninger, A

FA oxidation is an important energy source for cancer cells

However, when the H 2 O 2 concentration increases because of decreased expression or activity of catalase, it migrates to cytosol and other organelles, causing cell injury and participating in the Fenton reaction, resulting in serious oxidative stress