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Description

[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

However, oral B12 can be just as effective in increasing or maintaining B12 levels in those with no absorption issues

References Sikiric, P

Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health Journal of Endocrinology & Metabolism, Volume 4, Number 3, June 2014, Pages 64-77