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While both drugs act on the JAK/STAT signaling pathway, ritlecitinib results in inhibition of a narrower cytokine spectrum due to its selectivity for JAK3, whereas baricitinib inhibits both JAK1 and JAK2

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Houtkooper, R

Results obtained from randomized clinical trials, however, were inconsistent and in some circumstances have indicated that antioxidants increase cancer risk ( N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression ( From these data we can reasoned that by selectively targeting GSH content of cancer cells we can induce apoptosis either directly or by combining therapies with redox antineoplastic agents