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The recommended dose of pemetrexed for injection when administered with pembrolizumab and platinum chemotherapy for the initial treatment of metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered after pembrolizumab and prior to carboplatin or cisplatin on Day 1 of each 21-day cycle for 4 cycles

Specifically, decreases in P300 amplitude and longer latencies indicate a decline in cognition [49]

Whether this translates to humans remains unproven

And when those things are out of balance, you can start to notice increased levels of inflammation in your body