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To overcome this constraint, CNS-directed strategies often employ receptor-mediated transcytosis through engineered formats such as bispecific antibodies or brain-shuttle constructs targeting BBB receptors (e.g., TfR or insulin receptor) together with pathological targets such as A or tau, thereby improving brain delivery compared with conventional antibodies (Terstappen et al., 2021)

Black patients, women, older patients and those seen in endocrinology clinics had significantly lower odds of having documentation of a NAFLD diagnosis (Figure)

A radiometric assay was performed by RBC using 100M5 nM SAH as an inhibitor positive control

PML is a ROS sensor activating p53 upon oxidative stress