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Thus, the current developments highlight the intricate role of lipid-autophagy pathways in disease regulation, revealing lipid sensors and lipid exchange mechanisms that are critical for autophagosome formation and function, as well as small molecules that modulate these processes, offering potential therapeutic strategies for neurodegenerative diseases, cancer, and metabolic disorders

Furthermore, the mechanisms of TMZ resistance in glioma also involve DNA damage repair (DNA mismatch repair, base resection repair), abnormal cell signaling pathways (p53-mediated signaling pathway, reactive oxygen species-mediated signaling pathway, RTK-related signaling pathway, transforming growth factor -mediated signaling pathway, Wnt/-catenin signaling pathway), glioma stem cells, TME (hypoxic microenvironment, exosome), epidermal growth factor receptor, etc

Metabolic rate regulation

10.1016/j.jep.2022.115836 71 LiuH.ZhangT