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Proc Natl Acad Sci USA 95(6):29562960 Wallace DC (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

Chen W, Gao R, Xie X, Zheng Z, Li H, Li S, Dong F, Wang L

However, it should be noted that the trials were conducted in the same centers across the same time frame

Its multifactorial pathophysiology, progressive trajectory, and lack of disease-modifying treatments underscore the need for early, multi-targeted, and personalized approaches