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In the repair process, errors may occur, leading to the creation of LOF or GOF mutant alleles

Pretorius E, Mbotwe S, Bester J, Robinson CJ, Kell DB

Jenster G

In addition to ICB, CAR-T therapy is a cutting-edge cancer immunotherapy that genetically engineers a patients T cells to express chimeric antigen receptors (CARs), leading to targeted recognition and destruction of cancer cells