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Importantly, lupus T cells exhibit mitochondrial dysfunction, which is characterized by elevated mitochondrial transmembrane potential ( m ) or persistent mitochondrial hyperpolarization (MHP) that mediates diminished activation-induced apoptosis and predisposes T cells to pro-inflammatory death via necrosis (Gergely et al

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SYMPTOMS AND DIAGNOSIS Symptoms: Darkened Skin Under the Eyes: The primary symptom is the presence of darker pigmentation under the eyes compared to the surrounding facial skin