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Increasing evidence suggests that this axis exerts a profound influence on key neurobiological processes, including neuroinflammation, BBB permeability, neurotransmission, and synaptic plasticity, all of which are directly relevant to neurodegeneration and neuroprotection [615, 616]

Kaiserova M, Chudackova M, Prikrylova Vranova H, Mensikova K, Kastelikova A, Stejskal D, et al

doi: 10.1097/01.wcb.0000037988.07114.98 176 TanC.ShichinoheH.WangZ.HamauchiS.AbumiyaT.NakayamaN.et al

In rats, 2,4-dinitrophenol (DNP), a drug that promotes -oxidation in hepatocytes, reduced the hepatic lipid content and improved insulin sensitivity 66