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The intricate interplay between the microbiome, immune responses and HPV oncogene expression requires further investigation

Moreover, several studies have demonstrated that mutant KRAS also drives metabolic changes in cancers 1114 and that KRAS-driven metabolic reprogramming depends on the tissue of origin 15,16 , KRAS copy number 14 and mutation 34 (also reviewed in Kerk et al

10.3389/fmed.2020.585618 Front

In addition, oncogenic KRAS expression induces Arginase 1 (ARG1) expression in myeloid cells to break down arginine in the TME, thereby suppressing the activation of CD8 + T cells [144]