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Accumulated AGEs bind to membrane receptors on endothelial cells and promote the onset of tissue damage and the activation of the proinflammatory pathway that involves the NFB transcription factor responsible for regulating the expression of other inflammatory cytokines (Figure 4) [37]

The most common way for these organisms to enter wells is when the bacteria enter from the ground surface during well drilling, submersible pump installation, or any other construction, maintenance, or well servicing

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