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Interestingly, the L330S hFSP1 mutation can still partially rescue the resistance of HT1080 hFSP1 KO cells to RSL3, and significantly higher than that of mutation E156A (Fig

Thus, age-related impairment of the intestinal-renal arginine axis is more likely driven by reduced renal perfusion and altered arginine utilization than by a late-life decline in ASS1 itself [6]